Hi @mick-t,
The 200-300GB range seems accurate for a long running cryoSPARC instance. We have users that have reported larger sizes, but this is more rare. The database grows most proportionally with the number of jobs in the instance. Jobs create plots and figures, which are all downsampled and stored inside the database itself.
Please note that when you delete jobs, the database doesn’t release the space back to the OS; you will have to manually “defragment” the database in order to reclaim this space.
For more information on how to do this, please see this post: