Signal subtraction of nanodisc density

I was working with a map of transmembrane protein in nanodisc. However, after reaching 4Å map I was wondering if there’s any way to perform signal subtraction to get rid of lateral nanodisc density in CS.
I found a paper’s scheme which showed they could do it in Relion but not sure if and how I can do the same in CS.
Screen Shot 2022-04-04 at 5.15.11 PM

Please advise.


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You can certainly do this: Job: Particle Subtraction (BETA) - CryoSPARC Guide