Welcome to the forum @yongliang_zhang .
I wonder whether your cryoSPARC worker has sufficient DRAM and/or VRAM for the job as specified.
Please can you provide information about your computing environment.
The output of
cryosparcm joblog Px Jx
may also be useful.
Could the job compete with other significant workloads, of which the cryoSPARC scheduler may not be aware, for GPU and other resources?
Have you successfully completed homogeneous refinement with CTF/defocus optimization turned off and otherwise identical parameters?