I successfully installed CryoSPARC in May of this year and had already submitted jobs through the user interface, which ran without issues. However, a few months later, when I tried to start CryoSPARC again using cryosparcm start, I was unable to access http://localhost:39000/ due to a connection timeout. Could you please advise on what might be causing this? Could it be related to not updating the software? I am currently attempting to update to the latest version.
Welcome to the forum @AnnieYuan . Please can you
- confirm whether your web browser where you entered the
http://localhost:39000/is running on the CryoSPARC master computer or on another computer. - post the outputs of the commands (on the CryoSPARC master server):
cryosparcm status ps -eo user:12,pid,ppid,start,cmd | grep -e cryosparc_ -e mongo ls -l /tmp/mongo*.sock /tmp/cryosparc*.sock cryosparcm call env | grep -i proxy curl 127.0.0.1:39000 host localhost
-
the web browser is running on the CryoSPARC master computer.
-
here are the outputs.
[redacted]
![]()
Thanks. Please can you also post the outputs of the commands
cryosparcm call env | grep -i proxy
curl 127.0.0.1:39000
host localhost
here are the outputs
- cryosparcm call env | grep -i proxy
no_proxy=127.0.0.1, localhost, X29-UD4
- curl 127.0.0.1:39000
- host localhost
localhost has address 127.0.0.1
localhost has IPv6 address ::1
Thanks for posting the information.
The computer’s hostname and the network configuration may work for a single workstation-type CryoSPARC installation, but would not be suitable if you wished to add additional CryoSPARC worker nodes in the future.
Are you able to access the UI from a browser on the CryoSPARC master computer using the URL http://127.0.0.1:39000?
If the URL cannot be opened in the browser that’s running on the same computer as the successful curl 127.0.0.1:39000 command earlier, I wonder whether the browser ran with different proxy settings than the curl command. What command do you use to open the browser? If you opened the browser by pushing a button, the command may be found by inspecting the browser/button settings.


