I am currently solving several complexes each of which have a completely disordered domain. So much so that the domain has only shown up so far when I fix the complex with 0.1% glutaraldehyde. I have also solved the non-crosslinked version of the same complex, and it goes to higher resolution but this domain completely disappears from the map. This disordered domain is heavily glycosylated has also otherwise been refractory to structural studies in general. 3DVA itself is a very impressive tool, so this could be more of a hypothetical question but - would 3DVA work on a case like this? I am trying it anyway but curious if anyone has their experience to share.