Hi @OleUns, unfortunately the problem is not the pixel size – it’s the physical extent of the micrograph. I explain a bit more in this post, but essentially the denoiser requires the micrograph to be at least ~1500x1500 Å. If you downsample your micrograph the pixel size gets larger, but the micrograph gets smaller, so the physical extent remains too small for the denoiser to work.
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