Hi @david.haselbach,
I haven’t seem this error before, but if you want to try reinstalling cryoSPARC, you can. If cryosparcm backup is not working, you can keep a copy of your database (similar to what I explained here: How to change database directory in cryosparc v2?) in a different location. First make sure your instance is turned off cryosparcm status / cryosparcm stop. You can then try force reinstalling your instance, described here: https://cryosparc.com/docs/reference/install/#forced-update