Hi @mhaile! Welcome to the forum!
The 2D Classification algorithm does differ slightly between Live and “regular” CryoSPARC (there’s some discussion of this here), but in general, we expect their performance to be similar.
Can you describe what differences you’re seeing between the two jobs? Or, if you want, I’d be happy to take a look at your Live and regular 2D classes and we may be able to figure out a way to get a successful result for you!