In CryoSPARC v4.7, one can modify symbolic links inside a Live session using the commands
cryosparcm icli # from the Linux shell to the interactive icli
rtp.session_replace_symlinks('PX', 'SY', '/old/prefix/', '/new/prefix')
exit() # exit the interactive cli
or, on the Linux shell:
cryosparcm rtpcli "session_replace_symlinks('PX', 'SY', '/old/prefix/', '/new/prefix')"
Note that these commands do not work in versions below v4.7 and are subject to change in a future CryoSPARC release.