IOError: [Errno 32] Broken pipe

Hi @sunny1226, please check to see whether Cuda is set up correctly as noted here: Raise OSError('CUDA driver library not found')

If that doesn’t work run the cryoSPARC command line utility and inspect the output to ensure your environment is set up as expected:

cryosparcm env
cryosparcm status

Feel free to private message the output to me to help interpret it.

Nick