Dear CryoSPARC Community,
I would greatly appreciate your insights regarding the hardware configuration I’m considering for running CryoSPARC, particularly for single-particle analysis workflows. I’ve attached a system configuration screenshot (also summarized below), and I’m specifically looking for feedback on GPU compatibility and overall system suitability for high-throughput Cryo-EM data processing.
Key Specifications:
- CPU: Dual Intel Xeon Gold 6338 (32C/64T each)
- GPU: 2× NVIDIA RTX 5000 ADA (expandable to 4 GPUs total)
- RAM: 32GB DDR4 ECC RDIMM 3200 MHz (16 units supported)
- Storage:
- 1TB NVMe SSD (M.2, 2 units)
- 22TB SATA SSD (6 units, expandable)
- Motherboard/Chassis: 4U Rackmount, supports 12× PCIe 4.0 dual-slot GPUs
- RAID: LSI 3108 with 1GB Cache, RAID 0,1,5,6,10,50,60
- Networking: Dual 10GbE (Intel X710-AT2)
- OS: Ubuntu/CentOS (Open Source Linux)
- Software: Pre-installed Cryo-EM data processing stack (including CryoSPARC)
My main concern is whether the RTX 5000 ADA GPUs are fully compatible with the current CryoSPARC release and CUDA toolkit bundled with it. If anyone has experience using these ADA-generation cards with CryoSPARC, I’d love to hear about performance, compatibility, or any driver/CUDA version requirements or caveats.
Thank you in advance for your valuable feedback.
Warm regards,
Atul Kumar