Hi,
Multiple new reconstruction approaches (e.g. see AR-Decon: https://www.biorxiv.org/content/10.1101/2025.02.23.639707v1.full; GitHub - yifancheng-ucsf/AR-Decon: A deconvolution pipeline designed to enhance the quality of 3D cryo-EM maps that suffer from anisotropic resolutions.) used to mitigate map anisotropy benefit from being used in an iterative manner, ideally used to reconstruct the half maps used to initialize the next round of refinement/classification.
Would it be possible in the future to add support for a plug and play external reconstruction module in refinement and/or classification, to facilitate such approaches in difficult cases?
Cheers
Oli