ERROR during Ab Initio ERROR_ (AssertionError)

Hello,

I am running an Ab-initio reconstruction job. I first selected the best 2D classes from different particle tracers and extractions depending on the different major orientations.

I haven´t had any problems so far during this processing. I have run a remove duplicates in case that´s causing a problem. Also, the extraction box is 2x the diameter of the particle so It should be fine.

This is the error:

Traceback (most recent call last): File “cryosparc_master/cryosparc_compute/run.py”, line 129, in cryosparc_master.cryosparc_compute.run.main File “cryosparc_master/cryosparc_compute/jobs/abinit/run.py”, line 302, in cryosparc_master.cryosparc_compute.jobs.abinit.run.run_homo_abinit File “/opt/cryosparc/cryosparc_worker/cryosparc_compute/noise_model.py”, line 119, in get_noise_estimate assert n.all(n.isfinite(ret)) AssertionError

CryoSparc Version v4.7.1

Thanks in advance

Sergio BARATA

@baratachencho Please can you post the values of any parameters that you may have changed from their defaults for this job?

Hi,

I have changed nothing but the Number of classes to 4. Some particles may appear bad due to poor micrographs. I was quite relaxed during curating. Can that be possible?

Thanks

@baratachencho We would be interested in additional details. If you can, please can you retry variants of the failed job as described in Ab-Initio Reconstruction error - #3 by wtempel. For the test under 3. in that post, please try setting Number of Ab-Initio classes to 3.

Hi wtempel,

Thanks for the advice, I tried two of them:

  • Decrease the number of Ab-initio to 3 did not work; it crashed with the same error
  • Changing the noise model to White, on the contrary, It worked. Might you have an explanation for that? I was afraid that the picked particles where bad, from bad curate micrographs.

Thanks you for any help that you can provide

Sergio