Hi @arka,
Its worth a try. To re-compile cryoSPARC with a new version of CUDA, use the command cryosparcw newcuda <path_to_cuda> e.g. cryosparcm newcuda /usr/local/cuda-10.1
Also, what are your system’s details (OS, GPUs, CUDA Driver version)?
And what are the parameters of your 2D Classification job (# particles, # classes)?