Hi! @jenchem I would like to ask which kind of machine are you running 3d flex refinement on. As the issue (3D Flex pytorch issue on RTX4090 - #13 by wtempel) exists, I can not run 3d flex in cryosparc v4.2.1 on RTX 4090. I have confirmed that cryosparcw call nvcc --version returns 11.8. But in CryoSPARC v4.2.1, after running “/home/xx/cryosparc/cryosparc_worker/bin/cryosparcw install-3dflex” to install pytorch with CUDA version 11.8, it returns the “1.13.1+cu117”.