Hi @Jesse,
Sorry that you’re having memory issues with RBMC. I’m not sure that it will actually help you overcome the current problem, but if you’re interested, this post goes over the factors that affect the memory usage of RBMC: Memory issues with Reference Based Motion Correction? - #3 by hsnyder
I’ll also note that we’re planning to issue an update to RBMC in a future release of CryoSPARC that will help to reduce memory (RAM and VRAM demands).
– Harris