Unbinning particles using 'Downsample particles' job in CRYOSPARC (This is the right link) - If you are in the initial steps of 2D classification for cleaning, I bet you can downsample even further to gain speed. More experienced people might want to correct me, no problem with that, but IMO a pixel size of ~3 angstroms (maybe even bigger?) should still allow reliable classification. No?
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